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14 sty 2021 · Its elimination half-life is multiphasic as follows: in the first three to 10 days after drug withdrawal, amiodarone plasma concentration initially decreases by 50%, followed by a terminal half-life of 26 to 107 days, with a mean of around 53 days. 9 Following repeated intake of amiodarone, administered more frequently than its half-life ...
The effects of memantine were strongly voltage-dependent with a δ value of 0.89 and a Kd(0) value of 7.1 µM. Mutations at the critical asparagine residues in the M2 loop of NR1 and NR2B and at a tryptophan residue in M2 of NR2B reduced blocking by MK-801, memantine and TB-3-4.
31 sty 2024 · The elimination half-life is about 60 to 80 hours. Approximately 48% of the drug administered is eliminated unchanged in the urine. The remaining portion is transformed into 3 polar metabolites with minimal NMDAR antagonistic activity.
9 lis 1999 · The relatively short half-life for disappearance of amiodarone from plasma after intravenous administration is likely a measure of drug redistribution from vascular space into tissue and not true body elimination. 6 After long-term oral therapy, amiodarone has a true elimination half-life of up to 60 days. 7 8 9 Slow distribution to tissue ...
The terminal elimination half-life of memantine ranges from 60 to 80 hours in humans. 8,12 Following administration of a single oral dose of 10 mg/kg memantine in rats, the elimination half-life was 2.36 ± 0.20 hours.
24 lip 2023 · Estimates of the elimination half-life of amiodarone vary, depending on how the half-life has been measured and the route of amiodarone administration. After long-term oral therapy, amiodarone has a true elimination half-life between 60 and 142 days [2,3].
21 cze 2010 · After administration of a single dose of amiodarone, a wide interpatient variable initial half-life is found. This plasma half-life (α phase t 1/2α) represents the distribution into tissue compartments in which amiodarone is sequestered. Elimination from the peripheral and deep compartments (terminal elimination) is much slower and happens ...
