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24 lip 2023 · Estimates of the elimination half-life of amiodarone vary, depending on how the half-life has been measured and the route of amiodarone administration. After long-term oral therapy, amiodarone has a true elimination half-life between 60 and 142 days [2,3].
12 lis 2023 · Amiodarone possesses an exceptionally long half-life (t 1/2 of several weeks), and it may take up to 6 weeks to observe the complete clinical effects following oral therapy. In addition, after discontinuing amiodarone treatment, its pharmacological effects could persist for 1 to 3 months.
14 sty 2021 · Its elimination half-life is multiphasic as follows: in the first three to 10 days after drug withdrawal, amiodarone plasma concentration initially decreases by 50%, followed by a terminal half-life of 26 to 107 days, with a mean of around 53 days. 9 Following repeated intake of amiodarone, administered more frequently than its half-life ...
1 paź 2019 · Given the long half-life, it may take weeks before dose increases yield clinically apparent effects, suggesting the need for cautious and slow up-titration. Similarly, clinicians should be aware that the effects and toxicities of amiodarone can still be present weeks to months after stopping the drug.
2 wrz 2010 · Because the elimination half-life of memantine is approximately 70 hours, steady state is reached after 2 weeks. As steady state is approached, the difference in peak plasma concentrations between 20 mg once-a-day and 10 mg twice-a-day dosing diminishes ( Figure 1 ).
17 lut 2015 · Memantine has a long elimination half-life of approximately 70 hours, which results in little peak-to-trough concentration variations between doses at steady state (after 2 weeks of therapy). 2, 6 - 8 The soon-to-be-discontinued memantine tablets have been given once daily, which can promote medication adherence and appears to be well tolerated....
13 mar 2020 · The long half-life of amiodarone means that if it is withheld for a short period of time (up to 1 month) during long-term maintenance therapy, replacement therapy is not necessary. After amiodarone is discontinued, it may continue to have an effect for up to 3 months because of the prolonged half-life [ 8 , 9 ].
