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30 cze 2021 · Although targeted therapy has evolved in the last years and significantly improved the prognosis of patients with cutaneous melanoma, its use in vulvar and vaginal melanomas is still limited by the different mutagenic profiles involving fewer BRAF mutations and more c-KIT, NF1 and SF3B1 mutations [91,112]. Thus, monoclonal antibodies such as ...
22 maj 2020 · Objective. Melanoma comprises 5% to 10% of vulvar cancers and prognosis is poor. The purpose of this study was to identify prognostic factors and treatment patterns for vulvar melanoma using the National Cancer Database (NCDB). Methods. The NCDB was queried for patients with invasive vulvar melanoma from 2004–2015.
15 maj 2014 · Surgery is the preferred primary treatment for vulvovaginal melanoma, if feasible, and not requiring an exenterative procedure. The two main considerations in surgery are the management of the primary tumor and nodal assessment and management.
27 cze 2024 · Survival and Treatment Modalities in Primary Vaginal Melanoma—Case Report and a Narrative Review. by. Paweł Guzik. 1,*, Martyna Łukasiewicz. 2, Magdalena Harpula. 1, Paweł Zając. 1, Marcin Żmuda. 3, Marcin Śniadecki. 4 and. Paweł Topolewski. 2. 1. Clinical Department of Gynecology and Obstetrics, City Hospital, 35-241 Rzeszów, Poland. 2.
Overall survival at 2 and 5 years was 24% and 15%, respectively. Presence of lymph nodes at diagnosis was associated with worse overall survival (hazard ratio, 1.98; P = 0.02). Adjuvant radiation did not offer a statistically significant overall survival advantage compared to surgery alone.
1 gru 2020 · WLE with adequate margins is the mainstay treatment for early-stage vulvar melanoma while complete resection of the primary tumor is the standard treatment for early-stage vaginal melanoma. SLNB is the major treatment for vulvar melanoma, but its efficacy in vaginal melanoma remains to be defined.
OVERVIEW. Melanomas arising in the vulva and vagina are rare and therefore there is minimal data specific to these malignancies. Data are often extrapolated from other cutaneous melanomas, which may or may not be appropriate. Surgery remains the primary treatment modality at initial diagnosis and in select recurrent cases.
