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30 cze 2021 · Although targeted therapy has evolved in the last years and significantly improved the prognosis of patients with cutaneous melanoma, its use in vulvar and vaginal melanomas is still limited by the different mutagenic profiles involving fewer BRAF mutations and more c-KIT, NF1 and SF3B1 mutations [91,112]. Thus, monoclonal antibodies such as ...
1 paź 2024 · Survival in vulvar melanoma is superior to that of vaginal melanoma. • Most patients disease free five years after surgical resection received an adjuvant therapy. • Complete response to treatment of recurrence or progression was most frequent with nivolumab plus ipilimumab. • Overall survival for vulvar and vaginal melanomas did not ...
22 maj 2020 · Conclusions. Vulvar melanoma has a poor prognosis for those with regional and distant metastatic disease. Extent of disease, tumor size, and patient age are important prognostic factors. Other favorable factors included insurance and surgical management.
1 gru 2020 · WLE with adequate margins is the mainstay treatment for early-stage vulvar melanoma while complete resection of the primary tumor is the standard treatment for early-stage vaginal melanoma. SLNB is the major treatment for vulvar melanoma, but its efficacy in vaginal melanoma remains to be defined.
15 maj 2014 · Surgery is the preferred primary treatment for vulvovaginal melanoma, if feasible, and not requiring an exenterative procedure. The two main considerations in surgery are the management of the primary tumor and nodal assessment and management.
15 maj 2024 · Vaginal mucosal melanoma is an aggressive rare malignancy that requires early detection and appropriate management for improved survival. Surgery is the mainstay treatment and adjuvant treatment modalities should be used in high risk locally advanced settings.
20 wrz 2020 · Vulvar melanoma has a poor prognosis for those with regional and distant metastatic disease. Extent of disease, tumor size, and patient age are important prognostic factors. Other favorable factors included insurance and surgical management.
