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30 cze 2021 · Vulvar and vaginal melanomas are rare neoplasms, with aggressive evolution, most often diagnosed in advanced stages. Gynecological melanomas currently represent a discouraging diagnosis due to the absence of specific therapeutic guidelines and management measures with satisfactory results.
15 maj 2014 · Surgery is the preferred primary treatment for vulvovaginal melanoma, if feasible, and not requiring an exenterative procedure. The two main considerations in surgery are the management of the primary tumor and nodal assessment and management.
3 lis 2023 · The purpose of this guideline update is to collate evidence and propose evidence-based guidelines for the management and diagnosis of adult patients with vulval carcinoma treated in the UK. Malignant melanoma may present via similar routes and will be discussed.
27 cze 2023 · Treatment of advanced-stage vulvar cancer often involves multiple treatment modalities. Primary chemoradiotherapy can prevent the need for exenterative surgery, but in some cases surgery may be the treatment of choice.
1 paź 2024 · Median overall survival for vaginal melanoma in our cohort was 22.5 months and consistent with Joste et al. who reported a median survival difference favoring vulvar melanoma (62.4 versus 22.8 months) and hazard ratio for death of vaginal versus vulvar site of 8.56 (95 % CI, 1.95–37.64, p < 0.05).
Melanomas. Primary vaginal malignant melanomas are rare accounting for only 3% of melanomas of the female genital tract and 0.3%–0.8% of all melanomas in women. They are associated with poor survival outcomes with 5 year survival rates of 5%–25% due to their high tendency to metastasize and recur.
14 cze 2021 · While the mortality rate of cutaneous melanoma has dropped by 7% annually during the last 5 years, the prognosis of vulvar melanoma remains dismal: the 5-year overall survival rate is 47% compared with 92% for cutaneous melanoma.
