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7 kwi 2022 · The most common inherited thrombophilia is heterozygous factor V Leiden (FVL) mutation, which is acknowledged as a relevant risk factor for first VTE (17, 18). Earlier investigations suggest a moderately increased risk only and current guidelines do not suggest thrombophilia testing in unselected patients ( 1 , 19 – 26 ).
1 paź 1996 · Abstract. Background and Purpose Resistance to activated protein C is a common inherited risk factor for venous thrombosis, which is due to a mutation in coagulation factor V (factor V Leiden mutation). It is present in approximately 20% of unselected consecutive patients with deep vein thrombosis.
Factor V Leiden is a genetic disorder characterized by a poor anticoagulant response to activated Protein C and an increased risk for venous thromboembolism. Deep venous thrombosis and pulmonary embolism are the most common manifestations, but thrombosis in unusual locations also occurs.
14 lis 2010 · Factor V Leiden is a genetic disorder characterized by a poor anticoagulant response to activated Protein C and an increased risk for venous thromboembolism. Deep venous thrombosis and...
2 paź 2012 · In all cases, results from our calibrated APCR assay did not reflect the determined FV Leiden genotype. In cases 1 and 4, normal ratios (>2.1) were obtained, while gene testing showed heterozygosity (A/G) for the FV Leiden mutation. The individual in case 1 also had low factor V coagulant activity.
1 sty 2011 · Factor V Leiden is a genetic disorder characterized by a poor anticoagulant response to activated Protein C and an increased risk for venous thromboembolism. Deep venous thrombosis and pulmonary embolism are the most common manifestations, but thrombosis in unusual locations also occurs.
Clinically relevant coagulation factor (F)V deficiency results from the near‐complete absence of functional FV in plasma and platelets. It is inherited in an autosomal recessive fashion and has a population frequency of about one in a million; for a recent review, see Asselta et al. [1].
