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Melanoma in situ is an early form of primary melanoma in which the malignant cells are confined to the tissue of origin, the epidermis. It is also known as in-situ melanoma and level 1 melanoma.
Melanoma in situ is the earliest stage of melanoma (stage 0) and is localized to the outermost layer of skin (epidermis). It is regarded as a potential precursor lesion to invasive melanoma (stages I to IV), in which melanoma invades the deeper layers of the skin and, in doing so, acquires the potential ability to spread to distant sites, which ...
What is Stage 1 Melanoma? What is Stage 2 Melanoma? What is Stage 3 Melanoma? What is Stage 4 Metastatic Melanoma? Learn what the different stages of melanoma mean, from stage 0 to stage 4 metastatic melanoma and what factors doctors use to determine how advanced a melanoma is.
Melanoma in situ is also called stage 0 melanoma. It means there are cancer cells in the top layer of skin (the epidermis). The melanoma cells are all contained in the area in which they started to develop and have not grown into deeper layers of the skin.
Clinical malignant melanoma in situ (MMIS) is depicted in dark brown and subclinical spread of MMIS is represented in gray. The dark brown tumor is excised with 5 mm clinical margins in a 1:3 width-length ratio.
What is Stage 0 (in situ) Melanoma? In Stage 0 melanoma, the malignant tumor is still confined to the upper layer of the skin—the epidermis—which means the cancer cells are only in the outer layer of the skin and have not grown into the second layer of skin, called the dermis.
How is the stage determined? The staging system most often used for melanoma is the American Joint Committee on Cancer (AJCC) TNM system, which is based on 3 key pieces of information: The main (primary) tumor (T): How deep has the cancer grown into the skin? Is the cancer ulcerated?
