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11 sie 2022 · Laboratory findings include macrocytic anemia, low reticulocyte count, elevated erythrocyte adenosine deaminase in 80% to 85% of cases, and elevated HbF. BM examination shows normal cellularity with a paucity of erythrocyte precursors, or in severe cases, marked myeloid predominance . Genetic testing may be performed.
12 sty 2023 · Macrocytic anemia — Macrocytic anemia is defined as anemia with a high MCV (ie, ≥97.5 th percentile for age and sex ). (See 'Red blood cell indices' above.) The most common cause of macrocytosis in children is exposure to certain medications (eg, anticonvulsants, zidovudine , and immunosuppressive agents) [ 24,25 ].
8 lut 1997 · The causes of macrocytosis fall into two groups: (a) deficiency of vitamin B12 (cobalamin) or folate (or rarely abnormalities of their metabolism) in which the bone marrow is megaloblastic and (b) other causes, in which the bone marrow is usually normoblastic.
11 lip 2022 · Macrocytic anemia refers to macrocytosis (mean corpuscular volume (MCV) greater than 100 fL) in the setting of anemia (hemoglobin less than 12 g/dL or hematocrit (Hct) less than 36% in nonpregnant females, hemoglobin less than 11 g/dL in pregnant females, or hemoglobin less than 13 g/dL or Hct less than 41% in males).
In our cohort, iron deficiency was the most common cause of normocytic anemia in children. Specific iron testing with serum ferritin in the primary care setting would allow for treatment initiation with oral iron therapy.
15 cze 2010 · Normocytic anemia may be caused by chronic disease, hemolysis, or bone marrow disorders. Workup of normocytic anemia is based on bone marrow function as determined by the...
To that end, the primary aims of this paper are to outline definitions and classifications of anemia; describe the biological mechanisms through which anemia develops; review the variety of factors and conditions that contribute to anemia development, emphasizing those most prevalent in low- and middle-income countries (LMICs); and identify rese...
