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  1. 2 mar 2020 · In medical literature, the analgesic strength, or potency, of most painkillers is measured as a comparison to morphine. For example, oxycodone is roughly 50 percent stronger than morphine. Therefore, researchers might say the drug is 1.5 times as strong as morphine.

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  2. Oral Morphine Equivalents (OME) are approximations of the equianalgesic effects of other opioids compared to oral morphine. Thus, OMEs indicate how much of the reference drug oral morphine would be required to treat pain as effectively as the opioid morphine is compared with.

  3. The manufacturer of Transtec® recommends starting with the lowest strength patch. However, if the patient was already taking ≥120mg morphine orally or equivalent, the 52.5mcg/hr strength is suggested as the initial dose.

  4. Cross-tolerance: Many references recommend a cross-tolerance reduction between 25-50% when converting between unlike opioids. 9 In patients with very high opioid requirements, the difference between 25% and 50% can be a very significant discrepancy.

  5. A dose reduction of at least 50% is recommended when switching at high doses (eg, oral morphine or equivalent doses of 500mg/24 hours or more), in elderly or frail patients, or because of intolerable undesirable effects.

  6. Morphine Milligram Equivalents (MME) Calculator. Calculates total daily morphine milligram equivalents. IMPORTANT. There is no completely safe opioid dose, and this calculator does not substitute for clinical judgment. Use caution when prescribing opioids at any dosage, and prescribe the lowest effective dose.

  7. M360 Pill - white oval, 19mm Pill with imprint M360 is White, Oval and has been identified as Acetaminophen and Hydrocodone Bitartrate 750 mg / 7.5 mg. It is supplied by Mallinckrodt Pharmaceuticals.

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