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Serologic testing may reveal the presence of antibodies directed against double-stranded DNA (anti-dsDNA), Smith antigen (anti-Smith), U1 ribonucleoprotein (anti-U1RNP) and/or anti-Ro antibodies. In the vast majority of cases, the lupus band test, which is a DIF technique, is positive.
1 lip 2021 · Lupus erythematosus (LE) is a prototype of connective tissue disease with a variety of cutaneous and systemic manifestations. Microscopically, cutaneous LE is classically characterised by an interface dermatitis although other histopathological patterns also exist, depending upon the clinical presentation, location and chronicity of the skin ...
Cutaneous lupus erythematosus can be the presenting sign of SLE, as in acute CLE, or may evolve into SLE. Female patients with CLE and Ro/La autoantibodies should be advised of the risk their baby may have neonatal lupus erythematosus including congenital heart block.
11 lip 2023 · The lupus band test (LBT) is a direct immunofluorescence (DIF) technique which shows a band of localised immunoglobulins at the dermo-epidermal junction in lesional, non-sun-exposed skin of patients with both systemic and cutaneous lupus erythematosus (LE), and in perilesional skin of patients with systemic LE.
25 cze 2021 · The overall objective of the guideline is to provide up-to-date, evidence-based recommendations for the management of cutaneous lupus erythematosus (CLE) in the presence or absence of systemic lupus erythematosus (SLE) in adults, young people and children.
11 mar 2022 · Cutaneous LE can occur as a manifestation of systemic lupus erythematosus (SLE) or independent of SLE. The varying strengths of association between SLE and the individual subtypes of cutaneous LE are best illustrated in a graphic (figure 1).
21 kwi 2024 · Lupus erythematosus (LE) is an autoimmune inflammatory disease with complex etiology. LE may present as a systemic disorder affecting multiple organs or be limited solely to the skin. Cutaneous LE (CLE) manifests with a wide range of skin lesions divided into acute, subacute and chronic subtypes.
