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Lp-PLA2 participates in the breakdown of oxidized LDL in the vascular wall by hydrolyzing the oxidized phospholipid, producing lysophosphatidylcholine and oxidized free fatty acids, both of which are potent pro-inflammatory products that contribute to the formation of atherosclerotic plaques.
15 sty 2021 · For the Lp-PLA2 activity test, levels below 225 nmol/min/ml are normal . However, these numbers may vary depending on the laboratory performing the test. If your Lp-PLA2 levels are above the normal range, you may be at an increased risk for heart disease and stroke.
1 sty 2020 · In a prospective multiethnic cohort of 5,456 asymptomatic patients followed over a median of 10.2 years, Lp-PLA 2 activity was associated with an increased risk of incident cardiovascular...
The normal range for Lp-PLA2 is less than 200 ng/mL. If your results are higher, you may have inflammation in your arteries. When both your CRP and your Lp-PLA2 are higher, you may be at greater risk of having a stroke.
20 gru 2021 · What do the results of the LP-PLA2 test convey? The normal range of LP-PLA2 in your blood is 200 nanograms per milliliter (ng/mL). A higher value indicates that you are an increased risk of CVD including coronary artery disease and stroke.
se reactant. When disease is active in the artery, increased levels of Lp-PLA2 are produced by macrophages and foam cells within the intima of. the artery1. Lp-PLA2 also interacts with oxidized LDL, which increases inflammation and enhances a proatherogenic state, as well as plaque vu.
Lp-PLA2 is an enzyme encoded by the PLA2G7 gene located at chromosome 6p12-21, which is included in different signal transduction pathways. The potential of serum levels of Lp-PLA2 as a marker of inflammation quantifying cardio-metabolic risk, renal impairment and oxidative stress has been explored in earlier studies.
