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1 lis 2016 · This article summarizes legitimate reasons for prescribing benzodiazepines in the elderly, serious associated risks of prescribing them, particularly when not indicated, barriers physicians encounter in changing their prescription patterns, and evidence-based strategies on how to discontinue benzodiazepines in older patients.
12 sty 2015 · Long-term use can lead to dependence and withdrawal symptoms when discontinued. Benzodiazepines can impair cognition, mobility, and driving skills in older people, as well as increase the risk of falls.
recognize the risks associated with (long-term) benzodiazepine use, and (3) initiate/manage a benzodiazepine taper and name several alternatives to benzodiazepines for treating insomnia and anxiety in older adults.
1 mar 2024 · At first glance, this effect seems reasonable given BZRAs’ sedating effects in the elderly, possibly causing falls and fractures. The initial landmark case-control study of the effects of BZRAs on hip fracture rates that started the modern field of pharmacoepidemiology is a case in point ( 7 ).
• For those who have been taking a long half-life benzodiazepine for only a short-term (e.g. up to 4 weeks of clorazepate or clonazepam), taper over 1 week • Alprazolam • For doses <4mg/day, taper by no more than 0.5mg every 3 days or no more than 0.25mg every week
1 mar 2004 · Benzodiazepines with oxidative pathways and longer half-lives, such as chlordiazepoxide, diazepam, and flurazepam, are more likely to accumulate in the body and cause prolonged sedation . Furthermore, alterations in pharmacodynamics rather than pharmacokinetics among elderly patients can be more important in explaining the altered response to ...
A 72-year old woman with a psychiatric history of anxious depression and insomnia is receiving ongoing psychotherapy and psychotropic management. Her mood disorder has been stable with escitalopram (10 mg/d) for 3 years. She has been taking lorazepam (1 mg nightly) since the death of her husband 12 years ago.
