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20 lut 2023 · Ammonia exists as ammonium ion (NH4+) at the physiological pH and is produced in our body mainly by the process of transamination followed by deamination, from biogenic amines, from amino groups of nitrogenous base like purine and pyrimidine, and in the intestine by intestinal bacterial flora through the action of urease on urea.
1 lut 2017 · Since NH 4 + produced from glutamine metabolism is generated in mitochondria, ammonia transport from mitochondria to cytoplasm is a critical step in proximal tubule ammonia generation. AQP8 may play an important role in this process.
1 lis 2012 · Ammonium homeostasis is profoundly altered in liver failure resulting in hyperammonemia due to the deficient ammonium clearance by the diseased liver and to the development of portal collateral circulation that diverts portal blood with high ammonium content to the systemic blood stream.
1 mar 1984 · It is likely that ammonia has subtle but significant effects on tissue metabolism that are not apparent frown neuroiogic signs, in vitro urea cycle activity, or blood ammonia concentrations. Modestly el- evated concentrations of fluid ammonia in tissue reduce blood cell lifespan (32).
1 mar 2023 · Renal ammonia excretion is the predominant component of renal net acid excretion under basal conditions and in response to acid-base disturbances. Ammonia produced in the kidney is selectively transported into the urine or the renal vein.
Ammonium homeostasis is profoundly altered in liver failure resulting in hyperammonemia due to the deficient ammonium clearance by the diseased liver and to the development of portal collateral circulation that diverts portal blood with high ammonium content to the systemic blood stream.
28 sie 2020 · Tumor necrosis factor-alpha (TNF-α) promotes the transport of ammonia from the blood to the CNS and worsens the toxic effects of ammonia by upregulating RhCG in astrocytes and vascular endothelial cells.
