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15 wrz 2022 · A commonly accepted paradigm (based on Virchow’s triad of thrombogenesis) posits the pathogenesis of LV thrombus as occurring as a result of the interplay of 3 factors: (1) stasis attributable to reduced ventricular function, (2) endocardial injury, and (3) inflammation/hypercoagulability (Figure 1).
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- Linda S. Williams
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Background—The Randomized Evaluation of Long-term...
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Left ventricular (LV) thrombus formation is a well‐known...
- Intraventricular Thrombus Formation and Embolism in Takotsubo Syndrome
Objective: Takotsubo syndrome (TTS) is characterized by...
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- Peripartum Cardiomyopathy
Peripartum cardiomyopathy is a potentially life-threatening...
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Left ventricular (LV) thrombus is a feared complication of LV dysfunction associated with high rates of systemic embolism, morbidity, and mortality. Traditionally, LV thrombus has been associated with acute myocardial infarction (MI).
23 wrz 2022 · If OAC is initiated, a treatment duration might be 1–3 months, depending on bleeding risk. On the basis of reasonable data and evidence, post-MI patients with LV thrombus should be treated with OAC, typically for a duration of 3 months.
Management of LV thrombus (LVT) is challenging and crucial to prevent the potential development of thromboembolic complications such as stroke. Anticoagulation with warfarin is recommended for the prevention of thromboembolic events, but novel oral anticoagulants (NOAC) have been used in clinical practice without supporting evidence.
LVT should be considered a marker of increased long-term thrombotic risk that may persist even after thrombus resolution. Ongoing clinical trials are expected to elucidate the best management strategies for patients with LVT.
When asked what proportion of LVT found on echo would be verified on CMR, 51% stated <50%, 20% 50–75% and 29% >75%. Regarding frequency of cases seen annually, 41% reported seeing <20 cases and 8% >60 cases. For treatment, 66% preferred VKA whilst 30% used a DOAC (Figure 1).
15 wrz 2022 · Practical management suggestions in the form of text, tables, and flow diagrams based on careful and critical review of actual study data as formulated by this multidisciplinary writing committee are given.
