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Langerhans cells in an epidermal sheet from mouse skin. They are visualized by immunostaining with anti-major histocompatibility complex (MHC)-II antibodies in the large picture. The inset depicts double-labeling of MHC-II (green fluroescence) and langerin (red fluorescence).
- Langerhans Cells: Sensing the Environment in Health and Disease
Langerhans cells make up 3–5% of all nucleated cells in the...
- Langerhans Cells—Programmed by the Epidermis - PMC
Langerhans cells (LCs) reside in the epidermis as a dense...
- Langerhans Cells: Sensing the Environment in Health and Disease
Langerhans cells make up 3–5% of all nucleated cells in the epidermis and occupy the stratum spinosum, a suprabasal epidermal layer that is characterized by “spiny” keratinocytes that undergo reinforcement of their cytoskeleton.
Langerhans cells (LCs) reside in the epidermis as a dense network of immune system sentinels. These cells determine the appropriate adaptive immune response (inflammation or tolerance) by interpreting the microenvironmental context in which they encounter foreign substances.
15 kwi 2019 · Zimara et al. found that LCs catalyze early B-cell responses in skin-draining lymph nodes of L. major-infected mice. 51 T follicular helper cells and B-cell conjugates are crucial for B-cell differentiation and class switching following parasitic infection.
24 sie 2022 · Langerhans cells (LC) are a unique population of tissue-resident macrophages with dendritic cell (DC) functionality that form a network of cells across the epidermis of the skin. Their location at the skin barrier suggests an important role for LC as immune sentinels at the skin surface.
12 wrz 2018 · Langerhans cells (LCs) are classically viewed as unique antigen-presenting cells (APCs) that originate from embryonic precursors and maintain themselves independently in the epidermis. However, recent studies have demonstrated that murine LCs in mucosal epithelia arise and are continuously replenished from circulating bone marrow (BM) precursors.
Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the epidermal layer of the skin. Langerin is a lectin that serves as a valuable marker for LCs in mice...
