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27 mar 2023 · Key outcome measures include frequency of migraines attacks and intensity of headache pain. Additional exploratory outcome measures include changes in photosensitivity, retinal vascular diameter, and blood biomarkers of vascular tone.
27 mar 2023 · The primary objective of the LARGE trial is to evaluate the effectiveness of oral supplementation of L-arginine, AGE or the combined treatment of oral L-arginine and AGE, in reducing the severity and frequency of migraine attacks in chronic frequent episodic migraines in adults.
11 lis 2022 · This is the first in-human randomised double-blind placebo-controlled phase-II clinical trial examining the efficacy, safety and tolerability of L-arginine and AGE, in preventing chronic frequent episodic migraines by assessing participant-reported pain-related outcomes, and changes in photosensitivity and retinal vessels.
27 mar 2023 · Accumulating evidence suggests that cerebral arteries dilate during migraine, causing distal microvessels to constrict, which could activate nociceptors and cause onset of headache pain. If so, preventing or attenuating chronic microvascular constriction, and promoting a dilatory phenotype, may reduce frequency and/or severity of migraines.
7 cze 2023 · Learn what a new study discovered about the four most common OTC pain medications for migraine and the individual factors that may impact pain relief.
30 kwi 2013 · A single oral dose of ibuprofen 200 mg or 400 mg is effective in relieving pain in migraine headaches. Pain will be reduced from moderate or severe to no pain by two hours in just over 1 in 4 people (26%) taking ibuprofen 400 mg, compared with about 1 in 10 (12%) taking placebo.
4 maj 2006 · Headache response, pain-free, and sustained pain-free rates after 2 hours were significantly better in the 60-mg and 200-mg treatment groups, compared with those receiving placebo. The patients receiving 200 mg experienced the best results; 71% of these patients had headache response at 2 hours and 38% achieved pain-free status.
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