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8 paź 2024 · Pyroptosis, an immunogenic programmed cell death, could efficiently activate tumor immunogenicity and reprogram immunosuppressive microenvironment for boosting cancer immunotherapy.
9 lis 2023 · Despite advancements in cancer treatment, certain cancers still have a high risk of relapse and resistance owing to their inherent characteristics, including increased proliferation, angiogenesis, replication, invasiveness, metastasis, abnormal energy metabolism, immune evasion, and resistance to cell death [2, 3, 4].
10 lip 2024 · Pyroptosis, a form of programmed cell death, is closely connected to the inflammatory response, facilitating communication between innate and adaptive immunity [1, 2]. This emerging type of regulated cell death significantly influences cancer modulation, antitumor immunity, and the prognosis of cancer patients [2].
30 cze 2024 · Currently, studies in tumors have indicated that elevated levels of ROS can induce pyroptosis, which is beneficial in combating cancer. For example, the Nrf2/PPARα molecular axis in breast cancer overcomes chemotherapy resistance and leads to better clinical outcomes by promoting pyroptosis .
15 sie 2022 · Pyroptosis plays a dual role in cancer, and its ambiguous role is related to the cancer cell type, duration of pyroptosis induction, etc., so improper handling may even promote cancer...
15 sty 2024 · Emerging evidences have shown that pyroptosis contributes to many pulmonary diseases, especially lung cancer, and pneumonia. The exact roles of pyroptosis and gasdermin family proteins are tremendously intricate. Besides, there are evidences that pyroptosis contributes to these respiratory diseases.
22 sie 2024 · Pyroptosis, a lytic form of cell death mediated by the gasdermin family, is characterized by cell swelling and membrane rupture. Inducing pyroptosis in cancer cells can enhance antitumor immune responses and is a promising strategy for cancer therapy.
