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19 lip 2022 · In large conduit arteries, endothelial cells are exposed to high blood pressure and pulsatile circumferential stresses, both of which can cause damage. Endothelial cells at the sites of...
10 maj 2021 · Purkinje cell intrinsic firing deficits typically present peri-onset of behavioral dysfunction, and precede cell loss. Therapeutic strategies that rescue intrinsic firing deficits often improve behavioral deficits.
26 cze 2020 · Autophagy may be activated to overcome cell death; on the other hand, apoptosis may impair autophagy to complete cell death. When autophagic flux is impaired, autophagosome maturation is...
7 maj 2024 · Acute stress causes an increase in heart rate, stronger heart muscle contractions, dilation of the heart, and redirection of blood to large muscles. In contrast, chronic stress induces sustained activation of the sympathetic nervous system and HPA axis, leading to elevated levels of stress hormones such as cortisol and epinephrine. [13]
10 paź 2018 · Immune cell infiltration is a key driver of PAVT inflammation. In contrast to visceral fat, PVAT T cell infiltration may precede and exceed macrophage infiltration in animal models . Perivascular T cells represent a morphologically and functionally heterogeneous cellular population.
Deciphering the molecular mechanisms underlying PA-induced health benefits begins with defining the extent and magnitude to which PA disrupts homeostasis in different cell types, and how various cells react to meet those challenges.
17 sie 2017 · The spinocerebellar ataxias (SCAs) are a large and diverse group of autosomal-dominant, progressive neurodegenerative diseases. They share the clinical feature of progressive ataxia,...
