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16 paź 2020 · Isotope tracer experiments in humans and animals over several decades have offered insights into gluconeogenesis under euglycemic and diabetic conditions. This review focuses on the current understanding of carbon flux in gluconeogenesis, including substrate contribution of various gluconeogenic precursors to glucose production.
16 lut 2024 · When glucose is chemically "burned" as a fuel to produce carbon dioxide (CO 2) and water (H 2 O), the energy released from this oxidation process is 670 kcal/mol of glucose: C 6 H 12 O 6 + 6 O 2 → 6CO 2 + 6 H 2 O ΔH = -670 kcal/mol . The net energy yield from anaerobic glucose metabolism can readily be calculated in moles of ATP.
Isotope tracer experiments in humans and animals over several decades have offered insights into gluconeogenesis under euglycemic and diabetic conditions. This review focuses on the current understanding of carbon flux in gluconeogenesis, including substrate contribution of various gluconeogenic precursors to glucose production.
25 paź 2024 · Here, we introduce an automated pipeline designed for precise and robust quantification of metabolic activity from isotope tracing data. Metabolism encompasses a complex network of chemical ...
Understanding in vivo contributions of gluconeogenesis and glycogenolysis to glucose production has helped map the myriad pathways leading to glucose formation and has been invaluable in elucidating the redundancy and efficiency of the gluconeogenic process.
23 paź 2020 · Key Points. Carbon isotopes, 14 C and 13 C, in atmospheric CO 2 are changing in response to fossil fuel emissions and other human activities. Future simulations using different SSPs show continued changes in isotopic ratios that depend on fossil fuel emissions and, for 13 C, BECCS.
3 maj 2018 · One effective tracer is glucose labeled selectively at carbons 1 and 2 ([1,2-13 C]glucose). Catabolism of this tracer via the oxidative PPP, but not glycolysis, can produce M+1 labeled glycolytic metabolites ( Figure 6 D).
