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1 lip 2024 · Four studies have reported on the effects of CO2 exposure on brain activity during wakefulness [21, 22, 25, 26]. All four studies reported the impact of CO2 exposure on low-frequency EEG oscillatory activity, with two of them additionally detailing the effects on high-frequency EEG oscillatory activity [ 21 , 25 ].
19 kwi 2022 · These results and analysis suggest that CO2 mediates signaling between neurons and the cerebral vasculature to regulate brain blood flow in accord with changes in the neuronal activity.
Two mechanisms control brain blood flow by changing blood vessel diameter: autoregulation maintains flow in the face of perfusion pressure changes, and brain metabolism adjusts flow to meet metabolic requirements. Brain blood vessel reactivity to CO 2 and O 2 is an important component of the latter.
The neural control of CO 2 homeostasis relies on three processes: the chemoreflexes, central command, and somatic afferent feedback. The past decade has witnessed rapid progress in understanding the cellular, molecular, and integrative mechanisms underlying the chemoreflex regulation of breathing.
2 wrz 2015 · Specific brainstem neurons (e.g., retrotrapezoid nucleus, RTN; serotonergic) are activated by PCO2 and stimulate breathing. RTN neurons detect CO2 via intrinsic proton receptors (TASK-2, GPR4), synaptic input from peripheral chemoreceptors and signals from astrocytes.
2 wrz 2015 · Recent advances have clarified how the brain detects CO 2 to regulate breathing (central respiratory chemoreception). These mechanisms are reviewed and their significance is presented in the general context of CO 2 /pH homeostasis through breathing.
1 sty 2024 · The pioneering work of Kety and Schmidt ( 1946) demonstrated the effects of CO 2 on cerebral blood flow (CBF); hypercapnia induces dilation of cerebral arteries and arterioles and increases CBF, whereas hypocapnia causes constriction and decreases CBF.
