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The role of thiamine in cancer is controversial. However, thiamine deficiency may occur in patients with cancer and cause serious disorders, including Wernicke’s encephalopathy, that require parenteral thiamine supplementation. A very high dose of thiamine produces a growth-inhibitory effect in cancer.
24 lip 2013 · Thiamine’s key role in cancer cell metabolism and survival is further demonstrated by studies using the thiamine analog oxythiamine, which functions as an anti-coenzyme and is capable of reducing in vivo and in vitro tumor cell growth [62 - 64].
10 paź 2023 · Are B vitamin supplements safe for cancer patients to take during treatment? We went to clinical dietitian Juhina Farooki for answers to these questions and more. What are B vitamins, and how do our bodies use them?
24 lip 2013 · The alterations in thiamine homeostasis and increase in cancer cell proliferation with thiamine supplementation highlights a significant role for thiamine in cancer. Metabolic studies have provided strong evidence that cancer cells exploit thiamine-dependent enzymes and pathways for anabolic, proliferative, and survival purposes.
The objectives of this review are to (a) explain the mechanism by which thiamine (vitamin B 1) promotes nucleic acid ribose synthesis and tumor cell proliferation via the nonoxidative transketolase (TK) pathway; (b) estimate the thiamine intake of cancer patients and (c) provide background information and to develop guidelines for alternative ...
16 cze 2018 · In this study, we found that treatment of breast cancer MCF7 cells with high doses of thiamine over 24 h resulted in a significant reduction in the number of viable cells compared to untreated controls, but thiamine treatment did not affect the number of viable non-tumorigenic MCF10A cells.
Unfortunately, how thiamine reduces cancer cell proliferation is currently unknown. Recent focuses on metabolic targets for cancer therapy have exploited the altered regulation of the thiamine-dependent enzyme pyruvate dehydrogenase (PDH). Cancer cells inactivate PDH through phosphorylation by overexpression of pyruvate dehydrogenase kinases ...
