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  1. 22 mar 2023 · Dr. Hatoum and the research team discovered various molecular patterns underlying addiction, including 19 independent SNPs significantly associated with general addiction risk and 47 SNPs for specific substance disorders among the European ancestry sample.

  2. The researchers discovered a strong genetic correlation between problematic alcohol use and 138 other conditions, including substance abuse disorders, depression, and schizophrenia. “AUD has many variants across the genome that are involved in the predisposition of this trait, but these variants are not only predisposing to AUD, they are ...

  3. Briefly, findings from twin and family studies suggest common genetic factors shared amongst substance use (r g = 0.14–0.31 for alcohol, tobacco, and cannabis), with stronger estimates of shared genetic overlap amongst measures of problem use (r g = 0.56–0.62; Young, Rhee, Stallings, Corley, & Hewitt, 2006).

  4. This review outlines GWAS reports to date for nicotine, alcohol, or other drug addictions and focuses on common variants (mostly, single nucleotide polymorphisms [SNPs]) with robust evidence for association (i.e., identified at the standard genome-wide significance threshold [P<5×10 −8] and replicated in an independent dataset).

  5. 28 sty 2019 · As in most cases of psychiatric disorders, genetic and environmental factors interact to determine how vulnerable, or likely, you are to developing a substance use disorder. Drugs of abuse, including opioids, act on the brain's reward system, a system that transfers signals primarily via a molecule (neurotransmitter) called dopamine.

  6. 1 lip 2005 · Cross-inheritance studies in twins indicate that both substance-specific and substance-nonspecific genetic factors are important in addictions, and that there is cross-inheritance between...

  7. Understanding how genes cause biological differences can lead to improved treatments for substance use disorder. Each new addiction-related gene discovered is a potential “drug target.” Researchers can focus on the gene product (protein) and develop a drug to modify its activity.