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The effects of long-term L-arginine supplementation on kidney aging and the underlying mechanisms remain elusive. Moreover, high protein and high amino acid diet has been thought detrimental for kidney. We therefore investigated effects of chronic dietary L-arginine supplementation on kidney aging.
Background. Inducible, high-output nitric oxide (NO) production has been identified as a central mediator of cell injury in immune-mediated renal disease. In acute anti-thy-1 glomerulonephritis prefeeding with the NO precursor l -arginine increases mesangial cell injury and the subsequent fibrosis.
20 mar 2023 · However, some people, including those with conditions that affect the liver or kidneys, should avoid L-arginine .
6 sie 2024 · According to the National Institutes of Health (NIH), L-arginine doses of up to 9 grams (g) per day are usually safe for several weeks, but larger doses may cause adverse effects.
In contrast, l-arginine seems to be beneficial in experimental models of acute renal failure as well as in models of chronic renal disease such as renal ablation and ureteral obstruction. l-arginine also ameliorates renal injury in animal models of preeclampsia as well as in some models of hypertensive renal injury.
27 sie 2014 · Several disease are associated to an l -arginine impaired levels and/or to its metabolites: in particular various l -arginine metabolites may participate in pathogenesis of kidney and cardiovascular disease. l -Arginine and its metabolites may constitute both a marker of pathology progression both the rationale for manipulating l -arginine metab...
10 sie 2023 · L-arginine is considered to be generally safe. It might be effective at lowering blood pressure, reducing the symptoms of angina and PAD , and treating erectile dysfunction due to a physical cause. However, if you take a blood pressure drug, talk to your doctor before using L-arginine.
