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GH and IGF-1 are fundamental in achieving a normal longitudinal bone growth and mass during the postnatal period and, in association with sex steroids, play a major role in bone growth and development .
GH increases tissue formation by acting directly and indirectly on target cells; IGF-1 is a critical mediator of bone growth. Clinical studies reporting the use of GH and IGF-1 in osteoporosis and fracture healing are outlined.
Glucocorticoid-induced osteoporosis is the most common secondary cause of osteoporosis and the resulting fractures cause significant morbidity. Following initiation of oral glucocorticoids, rapid bone loss occurs, and fracture risk increases within a few months in a dose-dependent manner.
To investigate the correlations of levels of serum insulin-like growth factor-1 (IGF-1) and endothelin-1 (ET-1) with cytokines including interleukin (IL)-18, IL-6 and high-sensitivity C-reactive protein (hs-CRP) and bone material density in patients with osteoporosis d.
21 lis 2005 · Thus, it is apparent that significant new insights into the role of the IGF-I gene in bone remodeling occur through several distinct mechanisms: (1) the skeletal IGF regulatory system; (2) the systemic growth hormone/IGF-I axis; (3) parathyroid hormone signaling; (4) sex steroids; and (5) the OPG/RANKL/RANK cytokine system.
19 mar 2022 · Transforming growth factor beta 1 (TGF-β, which inhibits IL-1-induced bone resorption and stimulates osteoblast activity) is decreased by GCs. ( 110 ). Lower levels of TGF-β may increase the susceptibility of bone to the resorbing effects of IL-1.
18 lip 2024 · Since osteoporosis may develop even when low-dose or short-term GC therapy is used, each patient treated with corticosteroids, regardless of sex, age, corticosteroid dosage, treatment duration, or administration method, should be carefully assessed for the risk of fractures.
