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The use of benzodiazepines during pregnancy was associated with an increased risk of miscarriage (odds ratio [OR], 1.69; 95% CI, 1.52-1.87), and consistent findings were observed across multiple sensitivity analyses considering different time windows and accounting for misclassification.
15 maj 2020 · Our meta-analysis confirmed that benzodiazepine use before, during and after pregnancy is prevalent. The relatively common use of benzodiazepines with possible risks for both mother and (unborn) child is worrying and calls for prescription guidelines for women, starting in the preconception period. …
While earlier studies suggested an association between prenatal exposure to benzodiazepines and increased risk of cleft lip and palate, more recent studies have not demonstrated any increase in risk of congenital malformations. Recently there have been a series of new.
28 maj 2024 · However, women who took BZRDs during pregnancy tended to have higher risks for several adverse neonatal outcomes compared with pregnant women who had not taken these drugs. Future studies that consider the BZRD indication during pregnancy are still needed to verify our findings.
Keeping in view the potential risks of teratogenicity and direct neonatal toxicity, BZDs with established safety records should be used, while avoiding exposure in the first trimester, especially with multidrug regimens, and prescribing the lowest dose for the shortest duration.
The lowest effective dose should be used and only for as long as considered clinically necessary. The potential effects of diazepam use at any stage of pregnancy on fetal neurodevelopmental outcome is unknown.
Exposure to BZRDs during pregnancy may be associated with several adverse neonatal outcomes. However, we could not rule out the potential indication confounding factor, further studies with high-quality that control for important confounders are still needed to verify our findings.
