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6 cze 2022 · Iron homeostasis is mainly controlled by intestinal absorption because iron does not have active excretory mechanisms for humans. Thus, efficient intestinal iron bioavailability is essential to reduce the risk of iron deficiency anemia. There are two forms of iron, heme and nonheme, found in foods.
- PMC Free Article
Hypoxia-inducible factor-signaling upregulates the...
- Ferfer
Micronization and microencapsulation of iron into liposomes,...
- Comparison Study of Iron Bioaccessibility From Dietary Supplements and Microencapsulated Preparations
In the form of lactate, one tablet of dietary supplements...
- A Review
Iron absorption generally starts from the first part of the...
- Impact of Ascorbic Acid on The In Vitro Iron Bioavailability of a Casein-Based Iron Fortificant
Interestingly, a similar enhancement (i.e., by 1.18-fold p <...
- Biochemical and Nutritional Characteristics of Buffalo Meat and Potential Implications on Human Health for a Personalized Nutrition
They found an increased expression of genes involved in iron...
- PubMed
Based on the Institute of Medicine's review of the...
- PMC Free Article
Iron (Fe) Iron is an essential mineral required for a number of physiological functions including serving as an oxygen-binder and transporter, cellular respiration, regulation of cell growth and differentiation, electron transfer reactions, and the control of gene expression.
8 sie 2014 · Iron absorption is precisely regulated by a range of systemic and cellular mediators (Fig. 2). Liver-derived, circulating HEPC regulates duodenal iron absorption and also modulates iron release from stores in hepatocytes and RE macrophages (which recycle iron from senescent erythrocytes).
5 sty 2024 · Iron homeostasis involves careful coordination among intestinal iron absorption, the uptake and release of cellular iron, and iron storage. Due to the absence of a physiological mechanism for iron excretion in humans, control of intestinal iron absorption is the main mechanism, ensuring the overall iron balance.
Humans do not have the ability to remove excess iron and therefore iron homeostasis is maintained by regulating the amount of iron entering the body from the diet. Iron is present in the human diet in number of different forms, including heme (from meat) and a variety of non-heme iron compounds.
6 sty 2011 · The intracellular step of iron absorption refers to the intracellular distribution of the newly transported iron to the basolateral surface, to the mitochondria (e.g., biosynthesis of heme and iron-sulfur cluster), or to iron binding proteins (e.g., non-heme iron binding proteins and ferritin).
This article presents a brief overview of the molecular mechanisms of intestinal iron absorption and its regulation. While many proteins that orchestrate iron transport pathway have been identified, a number of key factors that control the regulation of iron absorption still remain to be elucidated.
