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1 mar 1998 · Absorption may be defined as the movement of iron from the intestinal lumen across the epithelial cells of the digestive tract into the circulation, while bioavailability generally refers to the proportion of iron in a given food or diet that the body can actually utilize.
8 sie 2014 · Iron absorption is precisely regulated by a range of systemic and cellular mediators (Fig. 2). Liver-derived, circulating HEPC regulates duodenal iron absorption and also modulates iron release from stores in hepatocytes and RE macrophages (which recycle iron from senescent erythrocytes).
6 sty 2011 · The intracellular step of iron absorption refers to the intracellular distribution of the newly transported iron to the basolateral surface, to the mitochondria (e.g., biosynthesis of heme and iron-sulfur cluster), or to iron binding proteins (e.g., non-heme iron binding proteins and ferritin).
21 wrz 2007 · This review describes the molecular mechanisms that co-ordinate the absorption of iron from the diet and its release into the circulation. While many components of the iron transport pathway have been elucidated, a number of key issues still remain to be resolved.
This article presents a brief overview of the molecular mechanisms of intestinal iron absorption and its regulation. While many proteins that orchestrate iron transport pathway have been identified, a number of key factors that control the regulation of iron absorption still remain to be elucidated.
24 lis 2011 · Several luminal factors, both in the diet and secreted by the gut, can have marked effects on the absorption of dietary iron. In studies of iron absorption in animals and humans, subjects are normally fasted before administering radioactively labeled iron into the intestine.
17 kwi 2023 · Once ferric iron is reduced to ferrous iron in the intestinal lumen, a protein on the apical membrane of enterocytes called divalent metal cation transporter 1 (DMT1) transports iron across the apical membrane and into the cell.
