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1 mar 1998 · This review summarizes current knowledge of and hypotheses on each of the three steps of iron absorption: uptake from the intestinal lumen into mucosal cells, transit through the cell, and release from the cells into the body.
6 cze 2022 · Iron homeostasis is mainly controlled by intestinal absorption because iron does not have active excretory mechanisms for humans. Thus, efficient intestinal iron bioavailability is essential to reduce the risk of iron deficiency anemia. There are two forms of iron, heme and nonheme, found in foods.
10 cze 2022 · Cellular absorption or iron from microcapsules was increased by 73%. Within 30 min of tea brewing, microcapsules reduced the formation of the iron–polyphenol complex in the tea by 60%. chelation: iron–casein complex with ascorbic acid: water and milk
Cellular iron export is regulated (reduced) by the liver hepcidin antimicrobial peptide (HAMP), which acts upon FPN1 to reduce iron export from the cells. HAMP is also induced by high Fe body stores and inflammation (via IL-6).
8 sie 2014 · Iron absorption is precisely regulated by a range of systemic and cellular mediators (Fig. 2). Liver-derived, circulating HEPC regulates duodenal iron absorption and also modulates iron release from stores in hepatocytes and RE macrophages (which recycle iron from senescent erythrocytes).
5 lip 2024 · Iron absorption takes place primarily on the duodenum of the small intestine through the enterocyte cell. Its levels in the human body are controlled only by absorption since unlike most other essential nutrients, it has no regulated excretory system in humans.
Iron absorption from the small intestine is regulated according to the body's needs, increasing in iron deficiency and decreasing in iron overload.
