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6 cze 2022 · Iron homeostasis is mainly controlled by intestinal absorption because iron does not have active excretory mechanisms for humans. Thus, efficient intestinal iron bioavailability is essential to reduce the risk of iron deficiency anemia. There are two forms of iron, heme and nonheme, found in foods.
- PMC Free Article
Supplementation with oral iron provides 60–80 mg iron/day,...
- Comparison Study of Iron Bioaccessibility From Dietary Supplements and Microencapsulated Preparations
In the form of lactate, one tablet of dietary supplements...
- A Review
Iron absorption generally starts from the first part of the...
- Impact of Ascorbic Acid on The In Vitro Iron Bioavailability of a Casein-Based Iron Fortificant
Interestingly, a similar enhancement (i.e., by 1.18-fold p <...
- Biochemical and Nutritional Characteristics of Buffalo Meat and Potential Implications on Human Health for a Personalized Nutrition
The human consumption of food animal products is the main...
- PubMed
Based on the Institute of Medicine's review of the...
- PMC Free Article
4 sie 2017 · Cellular iron homeostasis is maintained by iron and heme transport proteins that work in concert with ferrireductases, ferroxidases, and chaperones to direct the movement of iron into, within, and out of cells. Systemic iron homeostasis is regulated by the liver-derived peptide hormone, hepcidin.
10 cze 2022 · Dietary iron absorption is primarily performed through enterocyte cells on the duodenum and upper jejunum of the small intestine. Because humans do not have an active iron excretion system, intestinal iron absorption is critical for maintaining iron balance in the body.
8 sie 2014 · Iron absorption is precisely regulated by a range of systemic and cellular mediators (Fig. 2). Liver-derived, circulating HEPC regulates duodenal iron absorption and also modulates iron release from stores in hepatocytes and RE macrophages (which recycle iron from senescent erythrocytes).
22 mar 2024 · Cellular iron homeostasis is primarily regulated post-transcriptionally upon binding of iron regulatory proteins (IRP1 and IRP2) to iron-responsive elements (IREs) in the untranslated regions of the mRNAs for key proteins of iron metabolism (Figure 1A).
6 sty 2011 · The intracellular step of iron absorption refers to the intracellular distribution of the newly transported iron to the basolateral surface, to the mitochondria (e.g., biosynthesis of heme and iron-sulfur cluster), or to iron binding proteins (e.g., non-heme iron binding proteins and ferritin).
27 lis 2002 · In multicellular organisms, iron must be distributed from the site of absorption to cells that require iron. Genetic and molecular approaches have defined the mechanisms of iron uptake into absorptive cells and the subsequent transport of iron into plasma.
