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6 cze 2022 · Iron homeostasis is mainly controlled by intestinal absorption because iron does not have active excretory mechanisms for humans. Thus, efficient intestinal iron bioavailability is essential to reduce the risk of iron deficiency anemia. There are two forms of iron, heme and nonheme, found in foods.
- PMC Free Article
Supplementation with oral iron provides 60–80 mg iron/day,...
- Ferfer
Introduction. According to the global anemia prevalence...
- Comparison Study of Iron Bioaccessibility From Dietary Supplements and Microencapsulated Preparations
In the form of lactate, one tablet of dietary supplements...
- A Review
Iron absorption generally starts from the first part of the...
- Impact of Ascorbic Acid on The In Vitro Iron Bioavailability of a Casein-Based Iron Fortificant
Interestingly, a similar enhancement (i.e., by 1.18-fold p <...
- Biochemical and Nutritional Characteristics of Buffalo Meat and Potential Implications on Human Health for a Personalized Nutrition
They found an increased expression of genes involved in iron...
- PubMed
Based on the Institute of Medicine's review of the...
- PMC Free Article
10 cze 2022 · The standard definition of intestinal nutrient bioavailability is the portion of the absorbed and utilized nutrients from digested foods through enterocyte cells of the intestine. The absorption rate of iron has been reported as 25–30% in the consumption of organ meats, 7–9% in green leafy vegetables, 4% in grains, and 2% in dried legumes ...
8 sie 2014 · Iron absorption is precisely regulated by a range of systemic and cellular mediators (Fig. 2). Liver-derived, circulating HEPC regulates duodenal iron absorption and also modulates iron release from stores in hepatocytes and RE macrophages (which recycle iron from senescent erythrocytes).
4 sie 2017 · Cellular iron homeostasis is maintained by iron and heme transport proteins that work in concert with ferrireductases, ferroxidases, and chaperones to direct the movement of iron into, within, and out of cells. Systemic iron homeostasis is regulated by the liver-derived peptide hormone, hepcidin.
16 kwi 2021 · The Caco-2 human intestinal cell line has been widely adopted to mimic the in vivo small intestinal epithelium for screening the characteristics and mechanisms of the uptake, metabolism and absorption of dietary compounds and drugs.
both in rats and in Caco-2 cells, a cell line commonly used to study iron absorption and transport. With the use of confocal microscopy to determine the location of DMT1 in Caco-2 cells fed iron, it is possible to demonstrate that with iron feeding, DMT1 undergoes endocytosis and can be detected in the apical cytoplasm above the nucleus (Fig. 1 ...
6 sty 2011 · The intracellular step of iron absorption refers to the intracellular distribution of the newly transported iron to the basolateral surface, to the mitochondria (e.g., biosynthesis of heme and iron-sulfur cluster), or to iron binding proteins (e.g., non-heme iron binding proteins and ferritin).
