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14 maj 2021 · Hormone treatment is the treatment of choice for older women with ER-positive metastatic breast cancer; chemotherapy is suggested for ER-negative, hormone refractory, or rapidly progressing disease; single drug chemotherapy and combination oral chemotherapy are feasible options in older patients; dose reductions and schedule modifications are ...
1 gru 2022 · Women with high-risk early breast cancer (EBC) benefit from adjuvant chemotherapy, irrespective of age. 1,2 However, compared with younger and healthier women, older and more frail women with EBC experience increased chemotoxicity, resulting in dose reductions and treatment delays. 3-5
Adjuvant chemotherapy for early breast cancer patients improves survival in general, but estimating true benefit on the individual level remains a challenge, especially for older individuals.
14 gru 2023 · Integration of molecular genomic assays in diagnosis and treatment of estrogen receptor positive BC presents an opportunity for optimizing risk-tailored adjuvant therapies in ways that may permit treatment de-escalation among older women with early-stage BC.
14 maj 2015 · The decision to recommend chemotherapy to an older patient with early-stage breast cancer is complicated and requires knowledge of life expectancy, the risks and benefits of the proposed treatment, and the patient's and family's goals for treatment. 29 In general, for healthy older patients with estimated survivals of 10 years or more, state-of ...
14 maj 2009 · This trial shows that standard adjuvant chemotherapy with either CMF or doxorubicin plus cyclophosphamide is superior to capecitabine in older women with early-stage breast cancer. The benefit of...
30 lis 2020 · Use of chemotherapy in elderly patients with early-stage triple-negative breast cancer. December, 2020. Download Full Issue. Summary. Background. Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer associated with poor survival, in which adjuvant systemic treatments are limited to chemotherapy.
