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11 sty 2024 · In this article, we review the fundamental biology of γδ T cells, including their subtypes, expression of ligands, contrasting roles in and association with cancer prognosis or survival, as well as discuss the gaps in knowledge pertaining to this cell type which we currently endeavor to elucidate.
22 lis 2023 · In this comprehensive review, we explore the origin and fate of γδ T cells, their subsets, their relevance to various diseases including infections, autoimmune diseases, and cancer, as well...
22 lis 2023 · Initially, we elucidate functional differences between γδ T cells and their αβ T cell counterparts. We also provide an overview of major milestones in γδ T cell research since their discovery in 1984.
Gamma delta (γδ) T cells are a small subset of CD3-positive T cells in the peripheral blood but occur at increased frequency in mucosal tissues. The discovery of a second T-cell receptor 35 years ago was certainly unexpected [1, 2, 3, 4].
19 lut 2024 · γδ T cells are a unique subset of T lymphocytes and offer an attractive option for T cell-based immunotherapy due to their ability to secrete high levels of cytokines with anti-tumour functions while displaying features of both innate and adaptive immune cells. 2, 7, 8 These features, as well as the ability to recognise a broad range of ...
21 mar 2024 · Comprising only 1-10% of the circulating T cell population, γδT cells play a pivotal role in cancer immunotherapy due to their unique amalgamation of innate and adaptive immune features. These cells can secrete cytokines, including interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α), and can di …
Gamma/delta T (γδ T)cells possess a unique mechanism for killing tumors, making them highly promising and distinguished among various cell therapies for tumor treatment. This review focuses on the major histocompatibility complex (MHC)-independent ...
