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The hyperinsulinaemic-euglycaemic glucose clamp has always been regarded as the "gold standard" for the assessment of pharmacodynamic (PD) properties of insulin preparations; however, there has been controversy over a variety of methodogical details, such as study population, dosing time and the initial stabilization of blood glucose (BG ...
Insulin concentration is expected to rise almost 10 times during a 40 mU/min·m 2 clamp (from 6 ± 1 to 75 ± 5 mU/L and from 7 ± 1 to 82 ± 5 mU/L in healthy participants without obesity and participants with diabetes, respectively ).
12 lut 2018 · With the development of longer-acting basal analogue insulins, including glargine 300 (Gla-300) and insulin degludec (IDeg), results from numerous glucose clamp studies are readily available. However, interpreting PK/PD profiles in a scientifically sound manner can be a challenging feat.
Background: Observations by pharmacists monitoring anticoagulated patients suggested that patients with diabetes often require more frequent international normalized ratio (INR) monitoring than patients without diabetes. The purpose of this investigation was to examine the association between glycemic control and therapeutic anticoagulation ...
Methods: Thirty-nine glucose clamps were performed in 10 healthy and 29 subjects with type 1 diabetes (T1DM) (total duration 583 h). ClampArt-based BG measurements were compared with those obtained with a laboratory reference method.
12 cze 2012 · GDR determined from the hyperinsulinemic-euglycemic clamp and adjusted for weight, BSA, FFM, or FFM+17.7 was used as a biomarker for separating subjects who were insulin resistant (had type 2 diabetes mellitus) from those who were insulin sensitive (did not have type 2 diabetes).
7 sty 2016 · In this chapter, the standard protocol using the AP and the insulin resistance data are described in detail. By using an AP for the clamp, stable steady-state euglycemia and glucose infusion...
