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An immune complex, sometimes called an antigen-antibody complex or antigen-bound antibody, is a molecule formed from the binding of multiple antigens to antibodies. [1] The bound antigen and antibody act as a unitary object, effectively an antigen of its own with a specific epitope .
For example, immune complexes can form the following: persistent infection (e.g., streptococcus infection); production of antibody to self-antigen (e.g., systemic lupus erythematosus); or inhalation of antigenic materials from molds, plants, or animals (e.g., Farmer's lung and Pigeon fancier's lung).
It has been known for over 100 years that immune complexes can cause severe organ pathology. Many investigators have studied mechanisms of immune complexes mediated tissue destruction and how they contribute to the development of autoimmunity, but many critical aspects about immune complex function in causing disease are still unknown.
1 sty 2024 · Immune complexes, especially IgG ones, have several functions in activating and controlling phagocytes, including dendritic cells (DCs) and macrophages. DC maturation is more effectively induced by immune complexes than by an antigen alone.
19 lut 2017 · Foreign and modified self-antigens bind to natural IgM to form immune complexes (ICs). This facilitates the instructive phase of immunity, which programs immune response to generate class-switched high affinity antibodies required for IC formation, resulting in pathogen clearance. ICs are the first responders of immune challenge.
3 mar 2023 · Immune complex (IC) vasculitides present inflammations of vessel walls associated with perivascular deposition of immunoglobulins (Igs), mostly ICs. They encompass systemic and skin-limited variants of IgA vasculitis (IgAV), cryoglobulinemic vasculitis (CV), rheumatoid, lupus, and hypocomplementemic vasculitides, serum sickness cutaneous IgM ...
8 mar 2016 · Differences Between Animal Studies and Human Immune Complex Diseases. Many studies of IC-mediated pathology have relied on animal models, e.g., with transgenic mice. These models have been invaluable helpful to understand the development and progression of IC-dependent inflammation and lung injury.
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