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1 lut 2019 · IL-13 promotes the proliferation and differentiation of B cells, induces MHC class II, CD23, and IgE, enhances activation, aggregation and survival of eosinophils. In inflammation, IL-13 activates macrophages, promotes their anti-inflammatory properties and induces alternately activated macrophages and inhibits angiogenesis.
Interleukin (IL)-13 is a cytokine playing a pivotal role in T helper (Th)2 immune response supposed to be implicated in some intestinal disorders. IL-13 is produced by Th2 cells, natural killer T cell, innate lymphoid cells and innate immune cells, which contribute to trigger and maintain a chronic …
Allergen-specific IgE binds to high-affinity IgE receptors on mast cells and basophils (not shown), which, after cross-linking of IgE/FcϵRI complex, results in activation of these cells and release of mediators of allergic inflammation. Binding of IL-13 to IL-13R on activated macrophages induces an antiinflammatory state of these cells.
Previous studies have revealed that IL-13 is implicated in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), ulcerative colitis (UC), type 1 diabetes (T1D), sjogren's syndrome (SS), etc.
Interleukin 13 (IL-13) is a cytokine of increasing interest to gastroenterologists because of its developing role in ulcerative colitis, eosinophilic oesophagitis (EO) and fibrosis.
16 lip 2013 · Interleukin 13 (IL-13) is a cytokine of increasing interest to gastroenterologists because of its developing role in ulcerative colitis, eosinophilic oesophagitis (EO) and fibrosis.
Interleukin 13 (IL-13) is a cytokine that is responsible for promoting Th2 responses in humans and is released by T cells, mast cells, and eosinophils. It is typically associated with allergic inflammation, including asthma, but it also plays a role in fibrosis pathogenesis.
