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17 lip 2024 · As mice age, IL-11 is upregulated across cell types and tissues to regulate an ERK–AMPK–mTORC1 axis to modulate cellular, tissue- and organismal-level ageing pathologies.
A study in Nature in July 2024[1], raised the idea that blocking the interleukin 11 (IL-11) by using an IL-11 antibody could be a proposition for a healthy increase in lifespan, based on the outcomes in their experimental mouse subjects.
Notably, inhibition of ERK1/2 activation attenuated n-3 PUFA-induced hepatic IL-11 production and subsequent liver injury in APAP-treated mice, suggesting that n-3 PUFAs affect IL-11 production and APAP hepatotoxicity via regulation of the ERK1/2 signaling pathway.
24 lip 2024 · A protein called interleukin 11 (IL-11) appears to play a crucial role in aging, with scientists extending the lifespans of mice by up to 25 percent simply by blocking the molecule's effects.
17 lip 2024 · Scientists at the Medical Research Council Laboratory of Medical Science and Imperial College London have discovered that 'switching off' a protein called IL-11 can significantly increase the...
first-in-class IL-11Rα blocking antibody. METHODS: Using antibodies that are selective for mouse and human IL-11Rα, we examined the effects of IL-11 receptor blockade in additional animal models of tissue fibrosis and assessed IL-11-mediated increases in pro-inflammatory cytokine,
18 lip 2024 · Anti-IL-11 therapy boosted metabolism, with the animals producing calorie-burning brown fat, not problematic stores of white fat, blocked the loss of muscle mass and strength, and protected...
