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16 kwi 2019 · The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory responses that promote the rapid clearance of pathogens but also contribute to pathology in chronic inflammation.
3 cze 2024 · Interleukin (IL)-3 has long been known for its hematopoietic properties. However, recent evidence has expanded our understanding of IL-3 function by identifying IL-3 as a critical orchestrator of inflammation in a wide array of diseases.
11 lip 2023 · Interleukin-3 (IL-3) induces emergency hematopoiesis in settings of acute inflammation. In this issue of Immunity, Kiss et al. find that IL-3 derived from astrocytes and CD4 + T cells is a key regulatory cytokine of the central nervous system, and increased IL-3 signaling exacerbates neuroinflammation.
Dougan, Dranoff, and Dougan review the functions of the β common chain cytokines—GM-CSF, IL-3, and IL-5—in health and disease. They discuss current efforts targeting these pathways in the clinic and highlight important gaps in understanding of the basic biology of this cytokine family.
16 kwi 2019 · The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory responses that promote the rapid clearance of pathogens but also contribute to pathology in chronic inflammation.
The human IL-3 is characterized as a 32 kDa monomeric cytokine regulating the production and differentiation of multilineage hematopoietic progenitors from the bone marrow. IL-3 was first discovered in 1981 by Ihle et al. (1981) who purified this cytokine from concanavalin A-stimulated lymphocytes. At that date the only known ability of the new ...
8 gru 2023 · Using multiple murine models and human tissue, we have identified interleukin-3 (IL-3) as a molecular messenger between the central nervous and peripheral immune systems that shapes brain...
