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1. www.nature.com › articles › s41586/024/07701-9Inhibition of IL-11 signalling extends mammalian healthspan and...

   www.nature.com › articles › s41586/024/07701-9

   17 lip 2024 · Here we examined whether IL-11, a pro-inflammatory cytokine of the IL-6 family, has a negative effect on age-associated disease and lifespan. As mice age, IL-11 is upregulated across...

2. pubmed.ncbi.nlm.nih.gov › 39020175Inhibition of IL-11 signalling extends mammalian healthspan and...

   pubmed.ncbi.nlm.nih.gov › 39020175

   Treatment with anti-IL-11 from 75 weeks of age until death extends the median lifespan of male mice by 22.5% and of female mice by 25%. Together, these results demonstrate a role for the pro-inflammatory factor IL-11 in mammalian healthspan and lifespan.

3. onlinelibrary.wiley.com › doi › fullUnlocking longevity: How blocking IL‐11 signaling could extend...

   onlinelibrary.wiley.com › doi › full

   20 paź 2024 · We highlight a recent study published in Nature which explored the role of interleukin-11 (IL-11), a pro-inflammatory cytokine, in aging. 1 The study demonstrates how inhibiting IL-11 signaling can positively impact both healthspan and lifespan in mice, suggesting a novel target for antiaging therapies with significant implications for ...

4. immunityageing.biomedcentral.com › articles › 10Inhibiting IL11: a novel approach to turning back the clock

   immunityageing.biomedcentral.com › articles › 10

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   21 paź 2024 · Studies have shown that IL-11 inhibition can lead to improved health span and lifespan in animal models, with potential applications in humans. By targeting IL-11, researchers aim to mitigate age-related diseases, such as cancer, fibrosis, and multimorbidity, which pose significant healthcare challenges worldwide.

5. lms.mrc.ac.uk › scientists-find-master-switch-which-could-hold-the-key-to-longerScientists find “master switch” which could hold the key to...

   lms.mrc.ac.uk › scientists-find-master-switch-which-could-hold-the-key-to-longer

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   17 lip 2024 · Scientists at the Medical Research Council Laboratory of Medical Science and Imperial College London have discovered that ‘switching off’ a protein called IL-11 can significantly increase the healthy lifespan of mice by almost 25%.

6. www.cell.com › immunity › fulltextThe inflammaging clock strikes IL-11! - Cell Press

   www.cell.com › immunity › fulltext

   10 wrz 2024 · In a recent issue of Nature, Widjaja et al. examined genetic and pharmacologic inhibition of interleukin (IL)-11 on aging pathology and found that inhibiting IL-11 signaling increases lifespan and healthspan in mice.

7. www.researchgate.net › publication › 382331704_Inhibition_of_IL-11_signallingInhibition of IL-11 signalling extends mammalian healthspan and...

   www.researchgate.net › publication › 382331704_Inhibition_of_IL-11_signalling

   17 lip 2024 · In lifespan studies, genetic deletion of Il11 extended the lives of mice of both sexes, by 24.9% on average. Treatment with anti-IL-11 from 75 weeks of age until death extends the median lifespan...