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17 lip 2024 · The magnitude of lifespan extension remains to be fully determined but current data suggest that anti-IL-11 therapy given in late life increases median lifespan by more than 20% in both...
- Blocking IL-11 improves healthspan and lifespan in mice
In both male and female mice, the authors found that genetic...
- Blocking IL-11 improves healthspan and lifespan in mice
20 paź 2024 · We highlight a recent study published in Nature which explored the role of interleukin-11 (IL-11), a pro-inflammatory cytokine, in aging. 1 The study demonstrates how inhibiting IL-11 signaling can positively impact both healthspan and lifespan in mice, suggesting a novel target for antiaging therapies with significant implications for ...
21 paź 2024 · Studies have shown that IL-11 inhibition can lead to improved health span and lifespan in animal models, with potential applications in humans. By targeting IL-11, researchers aim to mitigate age-related diseases, such as cancer, fibrosis, and multimorbidity, which pose significant healthcare challenges worldwide.
Treatment with anti-IL-11 from 75 weeks of age until death extends the median lifespan of male mice by 22.5% and of female mice by 25%. Together, these results demonstrate a role for the pro-inflammatory factor IL-11 in mammalian healthspan and lifespan.
16 paź 2024 · For example, inhibition of IL-11 improved metabolism and muscle function, reduced ageing biomarkers and frailty, and led to an increase in lifespan.
10 wrz 2024 · In a recent issue of Nature, Widjaja et al. examined genetic and pharmacologic inhibition of interleukin (IL)-11 on aging pathology and found that inhibiting IL-11 signaling increases lifespan and healthspan in mice.
8 sie 2024 · In both male and female mice, the authors found that genetic or pharmacological blockade of IL-11 robustly extended median lifespan (by around 20% or more), with a reduced tumor burden upon...
