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1. www.nature.com › articles › s41586/024/07701-9Inhibition of IL-11 signalling extends mammalian healthspan and...

   www.nature.com › articles › s41586/024/07701-9

   17 lip 2024 · Administration of anti-IL-11 to 75-week-old mice for 25 weeks improves metabolism and muscle function, and reduces ageing biomarkers and frailty across sexes.

2. immunityageing.biomedcentral.com › articles › 10Inhibiting IL11: a novel approach to turning back the clock

   immunityageing.biomedcentral.com › articles › 10

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   21 paź 2024 · Studies have shown that IL-11 inhibition can lead to improved health span and lifespan in animal models, with potential applications in humans. By targeting IL-11, researchers aim to mitigate age-related diseases, such as cancer, fibrosis, and multimorbidity, which pose significant healthcare challenges worldwide.

3. www.nature.com › articles › s41580/024/00793-1IL-11 as a master regulator of ageing - Nature

   www.nature.com › articles › s41580/024/00793-1

   16 paź 2024 · Furthermore, the authors found that IL-11 inhibition has potent anti-ageing effects in both male and female mice, which suggests that it is a master regulator of senescence and ageing.

4. www.nature.com › articles › d41586/024/02300-0Blocking an inflammatory protein slows the pace of ageing -...

   www.nature.com › articles › d41586/024/02300-0

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   29 lip 2024 · 29 July 2024. Blocking an inflammatory protein slows the pace of ageing. Mice live longer and healthier lives when a cytokine protein called IL-11 is inhibited. The findings show how...

5. scitechdaily.com › breakthrough-in-anti-aging-il-11-deactivation-boosts-lifespanBreakthrough in Anti-Aging: IL-11 Deactivation Boosts ... -...

   scitechdaily.com › breakthrough-in-anti-aging-il-11-deactivation-boosts-lifespan

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   30 lip 2024 · Researchers from the Medical Research Council Laboratory of Medical Science and Imperial College London have discovered that ‘switching off’ a protein called IL-11 can increase the healthy lifespan of mice by nearly 25%.

6. www.cell.com › immunity › fulltextThe inflammaging clock strikes IL-11! - Cell Press

   www.cell.com › immunity › fulltext

   10 wrz 2024 · Chronic inflammation is considered a hallmark of aging. In a recent issue of Nature, Widjaja et al. examined genetic and pharmacologic inhibition of interleukin (IL)-11 on aging pathology and found that inhibiting IL-11 signaling increases lifespan and healthspan in mice.

7. medicalxpress.com › news › 2024-07-scientists-inflammatory-protein-longerScientists discover switching off inflammatory protein leads to...

   medicalxpress.com › news › 2024-07-scientists-inflammatory-protein-longer

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   17 lip 2024 · The results, published in Nature, were dramatic, with mice given the anti-IL-11 drug from 75 weeks of age until death having their median lifespan extended by 22.4% in males and 25% in...