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1 lut 2022 · Functionally, IL-33 acts both as alarmin and cytokine involved in type 2 immune responses driven by group 2 innate lymphoid cells (ILC2s), pro-inflammatory signalling via the IL-1R4/IL-1R3 complex, and regulatory responses as nuclear factor interfering with the p65 domain of the transcription factor NF-κB [20], [21].
ILCs have been recently divided in different functional subsets: group 1 ILCs includes NK and other IFN-γ-producing ILCs; group 2 ILCs includes cells that produce type 2 cytokines (IL-4, IL-5, IL-9 and IL-13); group 3 ILCs produce IL-17 and/or IL-22.
Specific IL-1 family cytokines are expressed by cells as cytosolic pro-forms that require cleavage for their activity and cellular release. IL-1β, IL-18, and IL-37 maturation and secretion is governed by inflammatory caspases within signaling platforms called inflammasomes.
18 sty 2010 · The action of interleukin-1 (IL-1) family cytokines on naive T cells and on the activation of early polarized T helper 1 (T H 1), T H 2 and T H 17 cells is indicated.
6 kwi 2022 · Interleukin-1 is a cytokine with potent inflammatory and immune-amplifying effects, mainly produced by macrophages during defensive reactions.
There are two cell surface IL-1 receptors, IL-1R1 and IL-1 type 2 receptor (IL-1R2), a decoy receptor. IL-1 binds to IL-1R1, which requires the formation of a heterodimer with the IL-1 type 3 receptor (IL-1R3) (also known as IL-1RAcP) accompanied by adaptor IL-1 receptor-associated kinase (IRAK) and myeloid differentiation primary response ...
13 lut 2014 · In this simplified diagram of the IL-1 signaling pathway, the signal initiates by the recognition of cytokines by IL-1 receptors and propagates via multiple sub-pathways involving family homologs or alternate pathways to activate transcription factors downstream.
