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The five primary classes of immunoglobulins are IgG, IgM, IgA, IgD, and IgE. These are distinguished by the type of heavy chain found in the molecule. IgG molecules have heavy chains known as gamma-chains; IgMs have mu-chains; IgAs have alpha-chains; IgEs have epsilon-chains; and IgDs have delta-chains.
- IGE
Properties of IgE: Molecular weight: 200,000; H-chain type...
- Introduction to Immunoglobulins
IgG and IgA are further grouped into subclasses (e.g., in...
- Immunoglobulin IgG Class
Properties of IgG: Molecular weight: 150,000 Da; H-chain...
- Antibody Isotyping and Characterization
Antibody screening, titering and isotyping are important...
- Introduction to Antibody Production & Purification
Antibody purification involves isolation of antibody from...
- Immunoglobulin IgA Class
IgA is a very weak complement-activating antibody; hence, it...
- Immunoglobulin IgM Class
IgM can recognize epitopes on invading microorganisms,...
- Antibody-binding Proteins
Protein A is generally preferred for rabbit, pig, dog and...
- IGE
Each immunoglobulin has two small chains (molecular weight of 22 kD) termed light chains (LCs) (Figure 1) and two more chains (55 kD) called heavy chains (HCs). Each IgG molecule is composed of two identical LCs and two identical HCs which form a Y-shaped structure (Figure 1).
IgG - Cys Periodic Table of Antibodies Fc containing antibodies Ab fragments Fc fusion proteins Fc domains Non-antibody proteins Number of Specificities 1 2 3 1. IgG 2. IgA 3. IgD 4. IgE 5. IgM 6. Fab 7. Fab2 8. scFv 9. dAb 10. Fc 11. Monomeric Fc 12. Hexameric Fc 13. Half antibody 14. scFv-Fc 15. dAb-Fc 16. Free LC 17. Long neck scFv-Fc
IgG antibodies are large globular proteins made of four peptide chains; [6] two identical γ (gamma) heavy chains of about 50 kDa and two identical light chains of about 25 kDa. The resulting tetrameric quaternary structure, therefore, has a total molecular weight of about 150 kDa. [7] .
24 cze 2022 · An IgG antibody comprises of heavy and light chains. It possesses the basic monomeric “H2L2” structure consisting of 2 identical Heavy (H) and 2 identical Light (L) chains. Its H-chain type is gamma (γ heavy chains) about 50 kDa in weight and each H chain is paired with an L chain of about 25 kDa.
23 sty 2024 · There are four subclasses of IgG: IgG1, IgG2, IgG3, and IgG4 which are differentiated on the position of interchain disulfide bonds, basis of the size of the hinge region and molecular weight along with differences based on the antigenic differences in structure of the heavy chain.
31 sie 2023 · The simplest antibodies, such as IgG, IgD, and IgE, are "Y"-shaped macromolecules called monomers. A monomer is composed of four glycoprotein chains: two identical heavy chains and two identical light chains. The two heavy chains have a high molecular weight that varies with the class of antibody.
