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This calculator is used to determine the concentration of IgG solutions using an absorbance reading at 280 nm. The concentration of any protein can be calculated by inputting the amino acid sequence or the UniProt ID.
IgG antibodies are large molecules, having a molecular weight of approximately 150 kDa, composed of two different kinds of polypeptide chain. One, of approximately 50 kDa, is termed the heavy or H chain , and the other, of 25 kDa, is termed the light or L chain ( Fig. 3.2 ).
Molecular weight: 900,000 Da; H-chain type (MW): mu (65,000 Da) Serum concentration: 0.5 to 2 mg/mL; Percent of total immunoglobulin: 10%; Glycosylation (by weight): 12%; Distribution: mostly intravascular; Function: primary response; Learn more about IgM
23 sty 2024 · IgG3 comprises around 5 to 10% of total IgG and has a molecular weight of 170 kDa. They play a major role in the immune responses against protein or polypeptide antigens which are T dependent antigens. The IgG3 are particularly good opsonins and mediators of ADCC because FcγRs bind sIgG3 antibodies with high affinity.
IgG antibodies are large globular proteins made of four peptide chains; [6] two identical γ (gamma) heavy chains of about 50 kDa and two identical light chains of about 25 kDa. The resulting tetrameric quaternary structure, therefore, has a total molecular weight of about 150 kDa . [ 7 ]
8 wrz 2020 · Immunoglobulins (Ig) or antibodies are glycoproteins produced by plasma cells. B cells are instructed by specific immunogens, for example, bacterial proteins, to differentiate into plasma cells.
Properties of IgG Antibody: Molecular weight: 150,000; H-chain type (MW): gamma (53,000) Serum concentration: 10 to 16 mg/mL; Percent of total immunoglobulin: 75%; Glycosylation (by weight): 3%; Distribution: intra- and extravascular; Function: secondary response
