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15 wrz 2017 · Among the various routes of drug administration, perhaps the least studied is intracerebroventricular (ICV) administration. This route has been shown to be particularly useful in administering to the central nervous system (CNS) drugs that do not cross the blood-brain barrier readily.
- Toxicologic Pathology Forum: Opinion on Interpretive Challenges for ...
This opinion outlines principal technical aspects of direct...
- Toxicologic Pathology Forum: Opinion on Interpretive Challenges for ...
Intracerebroventricular injection (often abbreviated as ICV injection) is a route of administration for drugs via injection into the cerebral ventricles so that it reaches the cerebrospinal fluid (CSF).
3 paź 2011 · In this video, we demonstrate the step-by step procedures involving two types of injection strategies that can be used to target the CNS: 1) direct injection into the CNS utilizing intracerebroventricular (ICV) injection; or 2) IV injection targeting the temporal/facial vein.
This opinion outlines principal technical aspects of direct CNS delivery via intracerebroventricular (ICV) or intrathecal (IT) injection to common nonclinical test species (rodents, dogs, and nonhuman primates) and describes procedure-related clinical and histopathological effects that confound interpretation of test article-related effects.
1 sty 2018 · For dogs treated by ICV injection, baseline MRI was performed to select the larger lateral ventricle for injection and to define the target coordinates. Injection was performed with a stereotaxic frame to accurately target the designated ventricle.
The intracerebroventricular (icv) administration is the most common method used to study the effects of a cytokine on the central regulation of feeding and drinking. Administration can be done into the lateral, third, or fourth ventricle.
For all studies, materials were administered into the cerebrospinal fluid (CSF) of test species via intracerebroventricular (ICV) injection (mice) or intrathecal (IT) injection (rats, dogs, and NHPs). Except for two of the rat studies that were single-dose, all studies had a repeat-dose design.
