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6 cze 2022 · Intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) elicits remission of diabetic hyperglycemia in rodent models of type 2 diabetes. Here, we present an optimized protocol to study the intracellular signaling pathways underlying the FGF1-induced sustained glucose lowering in the mouse brain.
Intracerebroventricular injection (often abbreviated as ICV injection) is a route of administration for drugs via injection into the cerebral ventricles so that it reaches the cerebrospinal fluid (CSF).
1 paź 2004 · To establish whether downregulation of neuropeptide Y (NPY) release by insulin is mandatory for its capacity to suppress glucose production, we examined the effects of a continuous intracerebroventricular (ICV) infusion of NPY (10 μg/h for 3–5 h) on glucose flux during a hyperinsulinemic-euglycemic clamp in mice.
30 cze 2017 · ICV injections of FGF19 in both ob/ob and DIO rodents yielded insulin-independent glucose lowering effects through a CNS-mediated mechanism, with acute improvements occurring within a few hours...
7 wrz 2020 · Each of these PNN-associated changes is reversed following a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) at a dose that induces sustained diabetes...
We recently reported that in rodent models of type 2 diabetes (T2D), a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) induces remission of hyperglycemia that is sustained for weeks.
1 lut 2002 · The infusion of oleic acid in the third cerebral ventricle resulted in a marked decline in the plasma insulin concentration (0.9± 0.1 vs. 2.1± 0.4 ng/ml) and a modest decrease in the plasma glucose concentration (139± 2 vs. 152± 3 mg/dl) compared with ICV vehicle (Fig. 1C and D).
