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However, their use has been associated with potentially serious dose-dependent gastrointestinal (GI) complications such as upper GI bleeding. GI complications resulting from NSAID use are among the most common drug side effects in the United States, due to the widespread use of NSAIDs.
Our findings indicate that ibuprofen at the concentrations of 100, 200, 300, 400, and 500 μM is able to reduce the cancerous characteristics of the AGS cells by inducing apoptosis, inhibition of cell proliferation, and angiogenesis.
8 sie 2009 · In a meta-analysis of NSAID use and cancer at sites other than the colon and rectum, González-Pérez et al. found that the possible protective effect of NSAIDs, as seen for colorectal cancer, potentially applies only to other gastrointestinal cancers such as those of the stomach and esophagus.
5 maj 2006 · In contrast, broad anticarcinogenic effects of NSAIDs have been demonstrated both in vivo using laboratory animals and in vitro using cancer cell lines. Chemically-induced gastric tumors can be reduced by aspirin[ 19 ], indomethacin[ 20 ], sulindac and ibuprofen[ 21 ] in mice.
27 gru 2014 · To this end, we have investigated the effects of ibuprofen on cell proliferation, apoptosis, angiogenesis, and expression of stemness marker genes, to understand the molecular mechanisms by which ibuprofen inhibits tumor growth in gastric cancer cells.
Like many other drugs, however, NSAIDs are associated with a broad spectrum of side effects, including gastrointestinal (GI) and cardiovascular (CV) events, renal toxicity, increased blood pressure, and deterioration of congestive heart failure among others.
Furthermore, the significance of adverse events is challenging to extrapolate. It is plausible that repeated exposure cumulatively increases the incidence of certain side-effects (e.g. ulcers of the gastrointestinal tract), potentially making single dose studies falsely reassuring.
