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In cases of moderate to severe pain caused by COVID-19 infections, opioids may be used for pain management; however, higher doses are required in those who use opioids, increasing the risk of toxicity and overdose .
3 gru 2020 · Opioid use at high doses and over several months could suppress immune system function and affect the prognosis for cases of COVID-19. However, it has been suggested that immunosuppression might play a protective role during COVID-19 infection.
4 wrz 2020 · About this guideline This living guideline from the World Health Organization (WHO) incorporates new evidence to dynamically update recommendations for covid-19 therapeutics. The GDG typically evaluates a therapy when the WHO judges sufficient evidence is available to make a recommendation.
5 sty 2022 · However, high doses of opioids might exacerbate the respiratory depression found in COVID-19 patients, their chronic use can trigger opioid tolerance and the higher doses used during the pandemic might result in greater adverse effects.
OBJECTIVE: The purpose of this narrative review is to discuss the available information regarding the currently utilized COVID-19 therapies (and the evidence level supporting them) and opioids for chronic pain with a focus on warnings of potential interactions between these two therapeutic approaches.
19 lis 2020 · However, in emergency situations such as ARDS from COVID-19 at the currently indicated dosages for treating dyspnoea, the benefits of using opioids could overcome the unpleasant side-effects, addressing both the viral infectious cycle and the host's response to the viral-induced pathogenesis.
Another study reported the effectiveness of an in vitro study according to the dose of indomethacin; the treatment with sustained-release formulation at a dose of 75 mg twice daily is expected to achieve a complete response within 3 days for the SARS-CoV-2 infection.
