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There was strong evidence of an increased risk of HIV acquisition with any prevalent HPV genotype from the meta-analysis (summary HR=2.06 (95%CI=1.44-2.94), I 2 =0%, P heterogeneity=0.66). All but one [25] of six studies in women presented a separate effect measure for HIV acquisition associated with high-risk HPV.
27 mar 2018 · HIV-positive women have higher risk of acquiring HPV, with risk inversely associated with CD4 cell count. ART lowered HPV acquisition, increased clearance, and reduced precancer progression, likely via immune reconstitution.
CD4 cell count in HIV-positive women is inversely associated with risk of HPV infection and cervical lesion progression. Further, several studies showed that women with high CD4 count (>500 cells/mm 3) had similar risk of HPV disease progression as HIV-negative women.
Here we review current insights into how HPV infection and the generation of anti-HPV immunity contribute to higher HIV transmission rates, and the impact of HPV on mucosal inflammation, immune cell trafficking, and epithelial barrier function.
1 lut 2018 · All these mechanisms and the high prevalence of HPV infection provide a biological basis for a possible increase in HIV transmission ascribed to HPV. Compromise of the immune system causes an increase in HPV acquisition, prevalence, persistence, and progression to disease.
16 lis 2020 · Expansion of HPV vaccination to areas with high HIV prevalence is especially important to achieve long-term reductions in the overall cervical cancer burden in those settings, as future birth cohorts might continue to be at high risk of HIV infection.
5 cze 2018 · The pooled crude RR for the association between HIV and incidence of HPV by CD4 count was higher for CD4 level ≤200 cells/μL (pooled RR = 6.65, 95% CI: 2.98 to 14.85; pooled aRR = 5.76, 95% CI: 3.65 to 9.08) than CD4 level >200 cells/μL (pooled RR = 3.20, 95% CI: 2.48 to 4.13; pooled aRR = 3.09, 95% CI: 2.17 to 4.40), but not statistically ...