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  1. Misoprostol tablets can be used either in the vagina, or under the tongue (sublingual). You and your doctor will discuss the best option for you. Using misoprostol in the vagina. Misoprostol tablets should be placed deep into the vagina two hours before your planned admission time. 1.

  2. Misoprostol has been extensively researched for its use in obstetrics and has proved to be a very effective cervical softening agent before termination of pregnancy. The beneficial effects on cervical ripening may make misoprostol a desirable agent for helping cervical dilatation on non pregnant women also.

  3. Figure 1: Safe single doses of vaginal misoprostol for producing uterine contractions at various gestations. For the first trimester 800µcg 24 hourly can be safely used. In the second trimester 200µcg 12 hourly is a common dose, whilst beyond 24 weeks 25µcg 6 hourly is usually used.

  4. 2. Route of administration of misoprostol. Both oral and vaginal administration of 400 g misoprostol is μ effective for cervical priming 3 h prior to vacuum aspiration [4]. Some studies found that vaginal administration is more effective than oral [13], while others found no difference between the two routes [19].

  5. In our study, we used 400 μg single dose of misoprostol by vaginal route 6 h prior to the procedures as a cervical priming agent. Our aim was to see the effectiveness of misoprostol by this approach. Though diagnostic hysteroscopy could be done using 4 mm scope without anesthesia in many cases.

  6. PATIENT & CAREGIVER EDUCATION. Misoprostol. This information from Lexicomp explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider. Brand Names: US. Cytotec. Warning.

  7. 29 lip 2012 · In this study we aimed to assess the efficacy of vaginal misoprostol for cervical ripening in premenopausal and postmenopausal women before dilatation and curettage in gynecological procedures such as endometrial biopsy.