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23 sty 2023 · Because of the plateau in the hemoglobin oxygen-binding curve, a small change in the oxygen content of the arterial blood causes a significant shift in PO2. As a result, right-to-left shunts result in more hypoxemia than hypercapnia.
Oxygen-deficient, carbon dioxide-rich blood returns to the right side of the heart through two large veins, the superior vena cava and the inferior vena cava. Then the blood is pumped through the pulmonary artery to the lungs, where it picks up oxygen and releases carbon dioxide.
15 mar 2024 · The increase in incidences of respiratory disease over the past decades has highlighted the importance of developing improved therapeutic approaches. This review will summarize recent research on the cellular complexity of the mammalian respiratory system with a focus on gas exchange and immunological defense functions of the lung.
24 lip 2020 · The primary function of the lungs is to facilitate gas exchange between inspired air and the circulatory system. It helps bring oxygen to the blood and remove carbon dioxide from the body. Oxygen is critical for proper metabolism on a cellular level, while carbon dioxide is crucial for achieving adequate PH levels.
The lung is a highly specialized organ that facilitates uptake of oxygen and release of carbon dioxide. Persistent inhalation of the invading pathogens or toxic agents may result in overwhelming production of ROS.
Within the lung, oxygen diffuses from the alveoli into the pulmonary capillaries, driven by the gradient between the partial pressure of oxygen in the alveolar space and that in the deoxygenated pulmonary capillary blood.
How do different cell populations in the lung communicate their metabolic needs, and does breaking this communication impact organ function or contribute to the development of disease? Why does the lung produce so much lactate, and is this important for proper growth and functioning of the lung?
